Inappropriate Polypharmacy and Deprescribing

Polypharmacy, the concurrent use of multiple medicines, has become increasingly prevalent as patient needs grow more complex. While appropriate in many cases, polypharmacy can introduce significant risks, including adverse drug interactions, increased side-effect burden, and diminished therapeutic value. These risks are particularly pronounced among older adults and those with multiple long-term conditions.

Inappropriate polypharmacy is associated with poorer patient outcomes, including a higher risk of adverse drug events, falls, hospital admissions, and reduced functional ability. It can contribute to confusion, medication errors, and a decline in quality of life. Optimising medication regimens is therefore essential for safeguarding patient safety, improving clinical effectiveness, and supporting independence.

Deprescribing is a structured, evidence-based approach to reviewing and reducing medicines that may no longer be beneficial or could be causing harm. It is central to optimising medication regimens and ensuring care remains person-centred and safe.

This site provides resources, guidance, and practical tools to support clinicians to tackle inappropriate polypharmacy to help deliver safer, more effective medicines optimisation for our population.